Which of the following are signs and symptoms of acute liver failure?

The signs and symptoms of acute liver failure are primarily related to liver dysfunction and its systemic effects. In this case, the combination of altered mental status (AMS), bleeding, jaundice, and elevated bleeding times clearly points to significant liver impairment.

Altered mental status occurs due to the accumulation of toxins in the bloodstream that the damaged liver can no longer effectively process. This can lead to confusion, drowsiness, or even coma as the brain is affected by these toxins, commonly seen in an encephalopathy scenario.

Bleeding is a result of coagulopathy, as the liver synthesizes essential proteins involved in blood clotting. In acute liver failure, the production of these proteins is severely compromised, leading to an increased risk of bleeding.

Jaundice is indicative of elevated bilirubin levels, which occurs when the liver is unable to process or excrete bilirubin due to its impaired function.

Elevated bleeding times reflect the liver's decreased ability to produce clotting factors, which is a hallmark of severe liver dysfunction.

These symptoms together create a picture that is characteristic of acute liver failure, making them the correct answer in the context of this question.